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Biblical History

The 185,000 Assyrian Army: Epidemiology and Herodotus on Sennacherib’s Siege

By Prof. Marcus Vance 9 min readAugust 2026
Sennacherib Assyrian army siege of ancient Jerusalem wall
Sennacherib Assyrian army siege of ancient Jerusalem wall

## The Siege of Jerusalem (701 BC) {#siege-context}

In 701 BC, Emperor Sennacherib led the Neo-Assyrian war machine across Judah, conquering 46 fortified cities including Lachish. He trapped King Hezekiah inside Jerusalem *"like a bird in a cage."*

Yet overnight, the siege collapsed without a single arrow being shot into Jerusalem.

Sennacherib’s Prism vs. 2 Kings 19

The **Taylor Prism** (cuneiform cylinder in the British Museum) lists Sennacherib’s conquests in detail. Intriguingly, unlike all other campaigns, Sennacherib *never claims to have captured Jerusalem*, nor does he record taking Hezekiah captive—an unprecedented omission confirming a sudden military catastrophe.

2 Kings 19:35 records: > *"That night the angel of the Lord went out and put to death a hundred and eighty-five thousand in the Assyrian camp."*

Herodotus Account of Field Mice Pestilence

Greek historian Herodotus (*Histories*, Book II.141) records an independent Egyptian/Levantine tradition regarding Sennacherib's army:

"A multitude of field mice poured in upon their adversaries... devoured their quivers, bows, and shield straps, so that the next day they fled defenseless, and many fell."

In ancient symbolism and medical history, **mice and rats were universal emblems of bubonic plague**.

Epidemiological Candidates: Yersinia Pestis vs. Cholera

Epidemiologists analyzing the overnight destruction of 185,000 troops point to **pneumonic plague** (*Yersinia pestis*) or acute **cholera / dysentery** spread via contaminated water supplies around Jerusalem. Pneumonic plague causes rapid respiratory collapse within hours, decimating densely packed military encampments.

Frequently Asked Questions

Does extra-biblical history confirm Sennacherib failed to take Jerusalem?

Yes, Sennacherib’s own Cuneiform Prism lists conquests of 46 cities but explicitly omits capturing Jerusalem or Hezekiah.

What disease killed the Assyrian army?

Epidemiologists and historians suspect pneumonic plague (Yersinia pestis) or acute bacterial dysentery, symbolized by field mice in Herodotus.